Listy Biometryczne - Biometrical Letters Vol. 37(2000), No. 2, 67-95
We consider two applications of optimum design theory to three examples. In design augmentation, trials are added optimally to an existing non-optimal design. In model checking we design for departures from an assumed model, but in a way that involves few extra trials. For both problems we find D-optimum designs. Special cases of the equivalence theorem for D-optimality provide algorithms for design construction and insight into the structure of the designs. Simple examples of designs for second-order response surface models over regular and irregular regions are followed by an application of the optimum non-linear design to field experiments on plant density.
Bayesian design, D-optimality, irregular region, non-linear model, response surface